Based on what happened next, I ASSUME
it means, "Would you like an enema?"
The Big Bang Theory Season 1, Episode 11
All right. Let's ASSUME ad arguendum,
that in this case Leonard is wrong.
The Big Bang Theory Season 3, Episode 7
Oh, I ASSUME the skills
can be extrapolated and transferred.
The Big Bang Theory Season 2, Episode 13
I ASSUME something bad
has happened.
The Big Bang Theory Season 12, Episode 10
Okay. All right.
Let's ASSUME your hypothesis.
The Big Bang Theory Season 2, Episode 1